1. Most human chromosomes are metacentric or submetacentric, but a small number are acrocentric, with the centromere located very close to one end.（大部分人类染色体是中央着、次着中央，但少数是接近末端的端着中央）

2. Acrocentric chromosomes are known for their role in certain genetic disorders, such as Down syndrome.（在某些遗传疾病，例如唐氏综合症中，端着中央染色体扮演着重要角色）