1、Severe hypothyroidism can lead to myxedema, a condition characterized by swelling, dryness, and puffiness of the skin.
严重的甲状腺功能减退症可以引起黏液性水肿，这是一种以皮肤肿胀、干燥和松懈为特征的疾病。

2、Treatment for myxedema usually involves hormone replacement therapy to restore normal thyroid function.
治疗黏液性水肿通常包括激素替代疗法，以恢复正常的甲状腺功能。